Müller cells express the cannabinoid CB2 receptor in the vervet monkey retina

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Müller cells express the cannabinoid CB2 receptor in the vervet monkey retina.

The presence of the cannabinoid receptor type 1 (CB1R) has been largely documented in the rodent and primate retinae in recent years. There is, however, some controversy concerning the presence of the CB2 receptor (CB2R) within the central nervous system. Only recently, CB2R has been found in the rodent retina, but its presence in the primate retina has not yet been demonstrated. The aim of thi...

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Cannabinoids exert their actions mainly through two receptors, the cannabinoid CB1 receptor (CB1R) and cannabinoid CB2 receptor (CB2R). In recent years, the G-protein coupled receptor 55 (GPR55) was suggested as a cannabinoid receptor based on its activation by anandamide and tetrahydrocannabinol. Yet, its formal classification is still a matter of debate. CB1R and CB2R expression patterns are ...

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Glia Cells of the Monkey Retina—II. Müller Cells

In this paper, for the first time a quantitative description of the morphology and distribution of Müller cells in the macaque monkey retina using immunohistochemistry and high resolution confocal laser scanning microscopy is given. By their morphological features Müller cells are ideally adapted to their neuronal environment in the various retinal layers, with a dense network of horizontal pro...

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Validating Antibodies to the Cannabinoid CB2 Receptor

The problem of antibody reliability in research has now reached the point where many journals reject any work that lacks adequate controls for antibody validation. Despite this, it is still common for researchers to rely on positive controls and only minimal negative controls (such as blocking peptide controls). Using careful cross-comparisons between antibody labeling and other labeling techni...

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Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys.

The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannab...

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ژورنال

عنوان ژورنال: Journal of Comparative Neurology

سال: 2013

ISSN: 0021-9967

DOI: 10.1002/cne.23359